Advances in sterol 14alpha-demethylase (CYP51).
- Author:
Jiaoyan YANG
1
;
Mingjun LIAO
;
Shao YANG
Author Information
1. College of Life Sciences, Central China Normal University, Wuhan 430079, China.
- Publication Type:Journal Article
- MeSH:
Cytochrome P-450 Enzyme Inhibitors;
Cytochrome P-450 Enzyme System;
genetics;
physiology;
Mutagenesis, Site-Directed;
Sequence Analysis, Protein;
Sterol 14-Demethylase
- From:
Chinese Journal of Biotechnology
2008;24(10):1681-1688
- CountryChina
- Language:Chinese
-
Abstract:
Sterol 14alpha-demethylase (CYP51), the most widely distributed member of the P450 superfamily, is the key enzyme in sterol biosynthesis pathway. CYP51 is not only an important model for fundamental P450 structure/function studies, but also an important target protein of cholesterol-lowering agents, antifungal drugs and herbicides. This article reviewed the research advances in CYP51 at various aspects, including sequence characteristics, physiological roles, catalytic properties in vitro, protein structure, structure-function relationships and inhibition of CYP51. The problems remained in current research and designations of CYP51 inhibitors are also discussed.
