The epidemiology of paediatric intussusception in Singapore: 1997 to 2004.
- Author:
Irving Charles BOUDVILLE
1
;
Kong Boo PHUA
;
Seng Hock QUAK
;
Bee Wah LEE
;
Htay Htay HAN
;
Thomas VERSTRAETEN
;
Hans Ludwig BOCK
Author Information
- Publication Type:Journal Article
- MeSH: Child, Preschool; Female; Humans; Immunization Programs; Incidence; Infant; Infant, Newborn; Intussusception; chemically induced; epidemiology; Male; Prospective Studies; Retrospective Studies; Risk Assessment; Risk Factors; Rotavirus; immunology; Rotavirus Infections; prevention & control; Rotavirus Vaccines; adverse effects; Singapore; epidemiology; Vaccination; adverse effects
- From:Annals of the Academy of Medicine, Singapore 2006;35(10):674-679
- CountrySingapore
- Language:English
-
Abstract:
INTRODUCTIONThe world's first rotavirus vaccine, Rotashield or RRV-TV, was registered in the US in 1998, but withdrawn within a year because of an observed association with intussusception (IS). Surveillance for IS has consequently become important in safety monitoring of new-generation rotavirus vaccines during development. Post-marketing surveillance is also important, and requires the availability of local baseline epidemiology data on IS.
MATERIALS AND METHODSAn eight-year study of IS in children under 2 years of age in Singapore was performed by retrospective review of admissions to KK Women's and Children's Hospital, the main paediatric hospital, from 1997 to 2001, followed by prospective surveillance of all hospitals from 2001 to 2004, using the case definition of the Brighton Collaboration Intussusception Working Group.
RESULTSThe average IS incidence was 60 per 100,000 in under-ones, and 32 per 100,000 in under-twos, with a downward trend between 1999 and 2004. Ninety-two per cent of subjects were aged below one year, with 51% aged 6 months to 11 months. The mean age at which IS occurred increased from 6.4 months to 12.5 months over the study period. The male-to-female ratio was 1.3:1. No trend in IS numbers was observed over different months of the year.
CONCLUSIONIS in Singapore shows no seasonality, but has demonstrated a trend of decreasing incidence in recent years. While highest in the first year of life, the risk of IS is increasing in the second year of life. Males have a slightly higher risk.