Photoacoustic Imaging for Differential Diagnosis of Benign Polyps versus Malignant Polyps of the Gallbladder: A Preliminary Study.
10.3348/kjr.2017.18.5.821
- Author:
Hee Dong CHAE
1
;
Jae Young LEE
;
Jin Young JANG
;
Jin Ho CHANG
;
Jeeun KANG
;
Mee Joo KANG
;
Joon Koo HAN
Author Information
1. Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Seoul 03080, Korea. leejy4u@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Photoacoustic technique;
Gallbladder neoplasm;
Gallbladder polyp;
Neoplastic polyp
- MeSH:
Adenocarcinoma;
Adenoma;
Cholesterol;
Diagnosis, Differential*;
Gallbladder Neoplasms;
Gallbladder*;
Humans;
Photoacoustic Techniques;
Polyps*;
Prospective Studies
- From:Korean Journal of Radiology
2017;18(5):821-827
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To investigate the feasibility of ex vivo multispectral photoacoustic (PA) imaging in differentiating cholesterol versus neoplastic polyps, and benign versus malignant polyps, of the gallbladder. MATERIALS AND METHODS: A total of 38 surgically confirmed gallbladder polyps (24 cholesterol polyps, 4 adenomas, and 10 adenocarcinomas) from 38 patients were prospectively included in this study. The surgical specimens were set on a gel pad immersed in a saline-filled container. The PA intensities of polyps were then measured, using two separate wavelength intervals (421–647 nm and 692–917 nm). Mann-Whitney U test was performed for the comparison of normalized PA intensities between the cholesterol and neoplastic polyps, and between the benign and malignant polyps. Kruskal-Wallis test was conducted for the comparison of normalized PA intensities among the cholesterol polyps, adenomas, and adenocarcinomas. RESULTS: A significant difference was observed in the normalized PA intensities between the cholesterol and neoplastic polyps at 459 nm (median, 1.00 vs. 0.73; p = 0.032). Comparing the benign and malignant polyps, there were significant differences in the normalized PA intensities at 765 nm (median, 0.67 vs. 0.78; p = 0.013), 787 nm (median, 0.65 vs. 0.77; p = 0.034), and 853 nm (median, 0.59 vs. 0.85; p = 0.028). The comparison of the normalized PA intensities among cholesterol polyps, adenomas, and adenocarcinomas demonstrated marginally significant differences at 765 nm (median, 0.67 vs. 0.66 vs. 0.78, respectively; p = 0.049). CONCLUSION: These preliminary results indicate that benign versus malignant gallbladder polyps might exhibit different spectral patterns on multispectral PA imaging.
