Correlation between Intravoxel Incoherent Motion Magnetic Resonance Imaging Derived Metrics and Serum Soluble CD40 Ligand Level in an Embolic Canine Stroke Model.
10.3348/kjr.2017.18.5.835
- Author:
Xiao Quan XU
1
;
Chen Jiang WU
;
Shan Shan LU
;
Qian Qian GAO
;
Qing Quan ZU
;
Xing Long LIU
;
Hai Bin SHI
;
Sheng LIU
Author Information
1. Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. liusheng@njmu.edu.cn
- Publication Type:Original Article
- Keywords:
Stroke;
Magnetic resonance imaging;
Diffusion-weighted imaging;
Intravoxel incoherent motion;
IVIM;
Experimental study
- MeSH:
Animals;
CD40 Ligand*;
Diffusion;
Dogs;
Infarction, Middle Cerebral Artery;
Magnetic Resonance Imaging*;
Perfusion;
Stroke*;
Thrombosis
- From:Korean Journal of Radiology
2017;18(5):835-843
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To determine the relationship between intravoxel incoherent motion (IVIM) imaging derived quantitative metrics and serum soluble CD40 ligand (sCD40L) level in an embolic canine stroke model. MATERIALS AND METHODS: A middle cerebral artery occlusion model was established in 24 beagle dogs. Experimental dogs were divided into low- and high-sCD40L group according to serum sCD40L level at 4.5 hours after establishing the model. IVIM imaging was scanned at 4.5 hours after model establishment using 10 b values ranging from 0 to 900 s/mm². Quantitative metrics diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) of ischemic lesions were calculated. Quantitative metrics of ischemic lesions were normalized by contralateral hemisphere using the following formula: normalized D = D(stroke) / D(contralateral). Differences in IVIM metrics between the low- and high-sCD40L groups were compared using t test. Pearson's correlation analyses were performed to determine the relationship between IVIM metrics and serum sCD40L level. RESULTS: The high-sCD40L group showed significantly lower f and normalized f values than the low-sCD40L group (f, p < 0.001; normalized f, p < 0.001). There was no significant difference in D*, normalized D*, D, or normalized D value between the two groups (All p > 0.05). Both f and normalized f values were negatively correlated with serum sCD40L level (f, r = −0.789, p < 0.001; normalized f, r = −0.823, p < 0.001). However, serum sCD40L level had no significant correlation with D*, normalized D*, D, or normalized D (All p > 0.05). CONCLUSION: The f value derived from IVIM imaging was negatively correlated with serum sCD40L level. f value might serve as a potential imaging biomarker to assess the formation of microvascular thrombosis in hyperacute period of ischemic stroke.
