Lignan glycosides and sucrose esters from roots of Securidaca inappendiculata.
10.19540/j.cnki.cjcmm.20170308.003
- Author:
Zhi WANG
1
;
Xue-Dong YANG
1
;
Hai-Yan ZHA
1
;
Li-Na GUO
1
;
Dan SHEN
1
;
Li-Zhen XU
2
;
Shi-Lin YANG
3
Author Information
1. School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
2. Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
3. National Engineering Research Center of Manufacturing Technique of Solid Preparations of Chinese Medicine, Nanchang 330006, China.
- Publication Type:Journal Article
- Keywords:
Securidaca;
Securidaca inappendiculata;
cytotoxic activity;
lignan glycosides;
sucrose esters
- From:
China Journal of Chinese Materia Medica
2017;42(12):2318-2322
- CountryChina
- Language:Chinese
-
Abstract:
Nine compounds, including five lignan glycosides (1-5), three sucrose esters (6-8), and one organic acid ester (9), were isolated from the ethanol extract of the roots of Securidaca inappendiculata by various chromatographic methods including silica gel, MPLC and preparative HPLC. Their structures were elucidated as acernikol-4″-O-β-D-glucopyranoside (1), (7R, 8S)-dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucopyranoside (2), (7R, 8S)-dihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside (3), (7R, 8S)-dihydrodehydrodiconiferyl alcohol 9'-O-β-D-glucopyranoside (4), (7R, 8S)-5-methoxydihydrodehy-drodiconiferyl alcohol 4-O-β-D-glucopyranoside (5), 3, 6'-O-diferuloylsucrose (6), 3-O-feruloyl-6'-O-sinapoylsucrose (7), sibricose A5 (8), and mehyl ferulate (9) on the basis of 1H-, 13C-NMR and MS experiments. Compounds 1-5, 8, and 9 were isolated from the Securidaca genus for the first time. Compounds 2, 3, and 7 exhibited weak cytotoxic activities against Hela and MCF-7 cell lines.
