Relationship and interactions between elevated fasting glucose and hypertension for cardiocerebral vascular disease
10.3760/cma.j.issn.0253-3758.2012.01.012
- VernacularTitle:空腹血糖和高血压对心脑血管疾病的交互作用研究
- Author:
Yi-Qiang ZHAN
1
;
Jin-Ming YU
;
Da-Yi HU
;
Yong MAO
;
Rong-Jing DING
;
Yihong SUN
;
Li-Jun ZHANG
;
Yuan-Yuan FU
;
She-Chang LI
;
Fen ZHANG
Author Information
1. 复旦大学
- Keywords:
Fasting glucose;
Hypertension;
Cardiovascular disease;
Transactional analysis
- From:
Chinese Journal of Cardiology
2012;40(1):57-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship and interaction of elevated fasting glucose and hypertension on cardiocerebral vascular disease.Methods 10 054 males and females were recruited for our cross-sectional study during May 2007 to August 2007.Unconditional logistic regression was used to analysis the relationship between fasting glucose and hypertension on cardiocerebral vascular disease.A product of fasting glucose and hypertension was added to the logistic regression model to evaluate the multiplicative interaction and relative excess risk of interaction(RERI),attributable proportion(AP)of interaction and synergy index(S)was applied to evaluate the additive interaction of the two factors.Bootstrap was used to calculate 95％ confidence intervals(CI)of RERI,AP and S.Results After adjusting age,gender,smoking,drinking,body mass index(BMI)and region,the product of fasting glucose and hypertension was not statistically significant,which means there was no multiplicative interaction between the two.But the additive indexes RERI,AP and S with 95％ CI of diabetes and hypertension were 0.64(0.03,1.25),0.27(0.01,O.47)and 1.83(1.02,5.13)respectively,which means significant additive interaction was shown between the two on cardiovascular disease but not no stroke.And there were no additive interaction bmtween impaired fasting glucose on cardiovascular disease or stroke.Conclusions Hypertension was independently related to cardiovascular disease and stroke in Beijing citizens,and diabetes were independently related to stroke.There was additive interaction between diabetes and hypertension on cardiovascular disease.
