Serum 25-hydroxyvitamin D concentration is negatively related to carotid artery intima-media thickness in type 2 diabetic patients
10.3760/cma.j.issn.0253-3758.2012.02.008
- VernacularTitle:2型糖尿病患者血清25-羟维生素D浓度与颈动脉内膜中层厚度的关系
- Author:
Jin-Xia LIU
1
;
Jie XIANG
;
Rui-Fang BU
;
Wen-Jun WU
;
Hong SHEN
;
Xia-Juan WANG
Author Information
1. 南京医科大学附属无锡市人民医院
- Keywords:
Diabetes mellitus,type 2;
25-hydroxy vitamin D;
Ultrasonography,Doppler
- From:
Chinese Journal of Cardiology
2012;40(2):115-119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between 25-hydroxy vitamin D [ 25 (OH)D ]and carotid artery intimal medial thickness (IMT) in type 2 diabetic (T2DM) patients.Methods Serum 25 (OH) D and carotid IMT were measured in 300 T2DM patients.Patients were divided into four quartile groups according to the serum 25 (OH) D levels( Q1:＜ 26.17 nmol/L,74 cases; Q2:26.17 - 32.75nmol/L,76 cases; Q3:32.75 -42.93 nmol/L,78 cases; Q4 ＞42.93 nmol/L,72 cases).Results Carotid IMT,carotid artery plaque prevalence,duration of diabetes,HbA1c,CRP and PTH were significantly higher in subjects with low 25 (OH)D compared subjects with high 25 (OH)D (P ＜ 0.05 ).Carotid artery IMT in Q1 and Q2 groups were significantly higher than that in Q4 group ( 1.03 ± 0.21 vs.0.90 ± 0.20,1.01 ±0.26 vs.0.90 ±0.20,P ＜ 0.05),was similar among Q1 and Q2 and Q3 groups.Prevalence of carotid atherosclerotic plaque in Q1 group (50.0％) was also significantly higher than in Q3 (29.5％,P ＜0.05 ) and Q4 ( 16.7 ％,P ＜ 0.05 ).Similarly,25 (OH) D concentration was significantly lower in patients with carotid plaque compared patients without carotid plaque [ (28.31 ±4.91 ) nmol/L vs.(36.31 ±4.31 )nmol/L,P ＜ 0.01 ].Pearson correlation analysis showed that carotid IMT was positively correlated with age,smoking,BMI,HbA1 c,CRP,LDL-C,PTH/25 (OH) D ratio (P ＜ 0.05 ),and was negatively correlated with 25 (OH) D ( r =- 0.51,P ＜ 0.01 ).Multivariate regression analysis showed that 25 (OH) D concentration was an independent predictor of carotid IMT in this cohort ( β =- 0.39,P ＜ 0.01 ).Conclusion Serum 25 (OH) D concentration is negatively correlated with carotid IMT and low 25 (OH) D level is a risk factor for preclinical atherosclerosis in T2DM patients.
