Comparison on efficacy and safety between domestic levosimendan versus dobutamine for patients with acute decompensated heart failure
10.3760/cma.j.issn.0253-3758.2012.02.015
- VernacularTitle:国产左西孟旦对比多巴酚丁胺治疗急性失代偿性心力衰竭
- Author:
Yu-Hui ZHANG
1
;
Jian ZHANG
;
En-Ming QING
;
Hui LI
;
Ying-Xian SUN
;
Lin ZHANG
;
Xiao-Juan BAI
;
Wen-Xian LIU
;
Yi-Nong JIANG
;
Peng QU
;
Bing-Qi WEI
;
Qiong ZHOU
;
Yan HUANG
Author Information
1. 中国医学科学院北京协和医学院阜外心血管病医院
- Keywords:
Heart failure,congestive;
Levosimendan;
Dobutamine
- From:
Chinese Journal of Cardiology
2012;40(2):153-156
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy and safety of domestic levosimendan versus dobutamine for patients with acute decompensated heart failure (ADHF).Methods ADHF patients from 8 medical centers were recruited in this multicenter,blind,positive-controlled,randomized study and received 24 h intravenous levosimendan (n =114) or dobutamine (n =114) therapy.SWAN-GANZ catheter was performed in patients with pulmonary capillary wedge pressure (PCWP) ≥ 15 mm Hg ( 1 mm Hg =0.133kPa) and cardiac index (CI) ≤ 2.5 L · min-1 · m-2 ( n =39 each).Results Compared with baseline level,LVEFincreased [(31.56 ±9.69)％ vs.(28.44 ±7.08)％,P＜0.01] at 24 h in both groups.LVEF increase at 24 h was similar between two groups [ ( 3.11 ± 6.90 ) ％ vs.( 3.00 ± 6.63 ) ％,P ＞0.05].The PCWP decrease at 24 h was significantly greater in levosimendan group than in dobutamine group [ ( - 8.90 ± 7.14) mm Hg vs.( - 5.64 ± 6.83) mm Hg,P =0.04 ].Decrease in NT-proBNP at 3 days was also more significant in levosimendan group than in dobutamine group [ the percentage change compared to baseline:( - 22.36 ± 38.98) ％ vs.( - 8.56 ± 42.42) ％,P ＜ 0.01 ].Dyspnea improvement at 24 h was more significant in levosimendan group than in dobutamine group.The incidences of adverse reactions and events were similar between two groups.Conclusion LVEF improvement is similar between dobutamine and domestic levosimendan while greater decreases in PCWP and NT-proBNP are achieved with domestic levosimendan in patients with ADHF.
