Association between serum uric acid and brachial ankle pulse wave velocity in Beijing community residents
10.3760/cma.j.issn.0253-3758.2012.03.006
- VernacularTitle:北京市社区人群血尿酸水平与肱-踝动脉脉搏波传导速度的关系
- Author:
Wei MA
1
;
Ying YANG
;
Li-Tong QI
;
Feng ZHAO
;
Bao-Wei ZHANG
;
Lei MENG
;
Yan ZHANG
;
Jie JIANG
;
Jian-Ping LI
;
Sai-Nan ZHU
;
Shu-Yu WANG
;
Yong HUO
Author Information
1. 北京大学第一医院
- Keywords:
Uric acid;
Cardiovascular diseases;
Community medicine
- From:
Chinese Journal of Cardiology
2012;40(3):204-208
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the relationship between serum uric acid and brachial ankle pulse wave velocity (ba-PWV) in Beijing community individuals.Methods This epidemiological survey was performed in residents of two communities from Shijingshan District in Beijing from 2007 to 2008.Cardiovascular risk factors and ba-PWV were measured. Two thousand five hundred and forty three individuals with both ba-PWV and serum uric acid measurements were included.Ba-PWV ≥ 1400 cm/s was defined as abnormal.The individuals were divided into four groups (Q1,Q2,Q3 and Q4 group) according to the gender-specific quartiles of serum uric acid. Univariate logistic regression was used to evaluate the relation between various cardiovascular risk factors and ba-PWV abnormality.Multivariate logistic regression was used to evaluate the relation between serum uric acid and ba-PWV abnormality after adjusting for other cardiovascular risk factors.Results Body mass index,triglyeride and prevalence of hypertension increased with increasing levels of serum uric acid (all P ＜0.01 ).Univariate logistic regression analysis showed that age,gender,smoking,hypertension,systolic blood pressure,diastolic blood pressure,diabetes,body mass index,total cholesterol,triglyeride and estimated glomerular filtration rate were related with ba-PWV abnormality( all P ＜0.01 ).Compared with Q1 group,ba-PWV abnormality OR value of Q4 group was 1.73 (95％ CI:1.34- 2.22,P ＜0.01 ).Multivariate logistic regression revealed that ba-PWV abnomality OR value of Q4 group was 1.66 (95％ CI:1.16 -2.37,P＜0.01 ) after adjusting for age,gender,smoking,hypertension,systolic blood pressure,diastolic blood pressure,diabetes,body mass index,total cholesterol,triglyeride and estimated glomerular filtration rate when compared with Q1 group and OR values were 1.55 (95％ CI:0.88 -2.74,P＞0.05) and 1.65 (95％ CI:1.04-2.64,P＜0.05) in male and female respectively.Conclusion Increased serum uric acid was independently associated with ba-PWV abnormality in Beijing community residents.
