Ex vivo assessment of coronary lesions by optical coherence tomography and intravascular ultrasound in comparison with histology results
10.3760/cma.j.issn.0253-3758.2012.04.009
- VernacularTitle:光学相干断层成像与血管内超声评价冠状动脉斑块的病理对照研究
- Author:
Jun GUO
1
;
Lu SUN
;
Yun-Dai CHEN
;
Feng TIAN
;
Hong-Bin LIU
;
Lian CHEN
;
Zhi-Jun SUN
;
Yi-Hong REN
;
Qin-Hua JIN
;
Chang-Fu LIU
;
Bao-Shi HAN
;
Lu-Yue GAI
;
Ting-Shu YANG
Author Information
1. 解放军总医院
- Keywords:
Tomography,optical coherence;
Ultrasonography,interventional;
Atherosclerosis
- From:
Chinese Journal of Cardiology
2012;40(4):302-306
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic accuracy of optical coherence tomography (OCT)and intravascular ultrasound (IVUS) in the detection of ex vivo coronary plaques with different compositions compared with histology results.Methods OCT and IVUS were performed in 15 autopsied heart specimens and the isolated coronary artery was assessed by routine histological processing thereafter.Coronary plaques were classified into 3 types (lipid-rich plaque,calcified plaque and fibrous plaque) according to standard criteria respectively.Sensitivity and specificity for detection of different types of plaque by OCT and IVUS were calculated according histology results.Results Seventy seven coronary plaques were analyzed.OCT demonstrated a sensitivity and specificity of 69％ and 88％ for lipid-rich plaque,93％ and 92％ for calcified plaque,88％ and 98％ for fibrous plaque.IVUS demonstrated a sensitivity and specificity of 61％ and 92％,98％ and 97％,68％ and 90％ respectively. The agreement between OCT and IVUS in assessment of coronary plaque was 0.831 ( Kappa =0.72,P＜0.01 ).Conclusions Both OCT and IVUS correctly detected ex vivo coronary plaques and there was a good agreement in assessment of coronary plaques between OCT and IVUS.OCT is superior to IVUS in assessment of fibrous plaque and is similar as IVUS in assessment of calcified plaque.
