Impact of metabolic syndrome on cardio-cerebral vascular events in pre-hypertensive population
10.3760/cma.j.issn.0253-3758.2012.05.009
- VernacularTitle:代谢综合征对高血压前期人群心脑血管事件的影响
- Author:
Shou-Ling WU
1
;
Ying ZHANG
;
Chun-Yu RUAN
;
Qi TIAN
;
Cheng JIN
;
Jin-Feng LI
;
Yu-Yan SUN
;
Wei HUANG
;
Ji-Wen ZHONG
;
Jun CAI
Author Information
1. 河北联合大学附属开滦医院
- Keywords:
Metabolic syndrome;
Hhypertension;
Cohort studies
- From:
Chinese Journal of Cardiology
2012;40(5):397-401
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study investigated the impact of metabolic syndrome on the development of cardio-cerebral vascular (CVD) events in a pre-hypertensive population.Methods The data used in this prospective study was derived from the Kailuan study cohort ( n =101 510).Prehypertension was diagnosed in 29 968 (mean age:50 ±9 years and 23 744 males) individuals by the JNC Ⅶ criteria and these subjects were further classified into metabolic syndrome positive ( MS +,n =3447) and MS negative ( MS -,n =26521 ) groups according to the modified 2004 Chinese Diabetes Society criteria.Subjects were followed up for 38- 53 (mean 47 ± 5 ) months and first-ever CVD events were recorded.Baseline anthropometric and laboratory features were obtained by physical examination from June 2006 to October 2007 and the last follow-up day was December 31,2010.Multivariable Cox proportional hazards regression models were used to analyze the risk factors of first-ever CVD events.Results There were 354 CVD events during follow up.The incidences of CVD events ( 1.80％ vs. 1.28％ ) and cerebral infarction ( 1.10％ vs.0.57％ ) were significantly higher in the MS + group than in the MS - group ( all P ＜ 0.05 ).After adjustment for other established CVD risk factors,the hazards ratio was 1.45 (95％CI:1.10 -1.92) for total CVD events and 1.84 ( 95％ CI:1.27 - 2.67 ) for cerebral infarction events in MS + group.Conclusions In this cohort,metabolic syndrome is linked with increased risk for CVD events.
