Predictive value of corrected QT interval, corrected Tp-e interval and Tp-e/QT ratio on malignant arrhythmia events in acute ST-segment elevation myocardial infarction patients undergoing thrombolysis
10.3760/cma.j.issn.0253-3758.2012.06.004
- VernacularTitle:急性心肌梗死溶栓前后校正QT间期、校正Tp-e间期、Tp-e/QT的变化及其预测价值
- Author:
Wen-Tao XIAO
1
;
Xian-Pei WANG
;
Chuan-Yu GAO
;
Juan-Juan YAN
;
Mu-Wei LI
;
You ZHANG
;
Jing-Jing LIU
Author Information
1. 郑州大学人民医院
- Keywords:
Myocardial infarction;
Electrocardiography;
Thrombolytic therapy;
Forecasting
- From:
Chinese Journal of Cardiology
2012;40(6):473-476
- CountryChina
- Language:Chinese
-
Abstract:
Objective The prognostic value of corrected QT interval(QTc),corrected Tp-e interval (Tp-ec) and Tp-e/QT ratio on occurrence of malignant arrhythmia events (MAE) in acute ST-segment elevation myocardial infarction (STEMI) patients underwent successful thrombolysis was explored and the potential association of these indices with MAE was analyzed.Methods Fifty-seven STEMI patients underwent successful thrombolytic therapy within 6 hours after admission and conservative medical treatment were included.QTc,Tp-ec,Tp-e/QT ratio were obtained and calculated in infarct-related electrocardiograph leads and non-infarct-related leads before thrombolysis,(7 ± 1 ) days and (30 ±3 ) days after thrombolysis respectively,and incidence of MAE up to 30 days after thrombolysis was analyzed.Sixty age and gender matched normal subjects served as control group.Results ( 1 ) QTc,Tp-ec,Tp-e/QT in infarct-related and non-infarct-related leads in STEMI group before thrombolysis were significantly higher than those in control group( all P ＜0.05 ),and values from the infarct-related leads were significantly higher than those from non-infarct-related leads in STEMI group ( all P ＜ 0.05 ).QTc,Tp-ec and Tp-e/QT all significantly and continuously reduced from 7 days and at 30 days post thrombolysis compared the before thrombolysis( P ＜0.05 vs.before thrombolysis).( 2 ) Tp-ec ≥ 100 ms and Tp-e/QT ratio ≥0.25 before thrombolysis in infarct-related leads were linked with higher incidence of MAE within 30 days post thrombolysis in this patient cohort [28.1％ (9/32) vs.40％ ( 1/25),27.8％ (10/36) vs.0,respectively,all P ＜ 0.05 ].Conclusion QTc,Tp-ec and Tp-e/QT values decreased post successful thrombolysis in STEMI patients and higher Tp-ec and Tp-e/QT values before thrombolysis in STEMI patients were related with higher MAE incidence up to 30 days post successful thrombolysis in this patient cohort.
