Increased platelet-leukocyte aggregates in patients with acute coronary syndrome
10.3760/cma.j.issn.0253-3758.2012.06.006
- VernacularTitle:血小板-白细胞聚集体与急性冠状动脉综合征的相关性
- Author:
Da-Hao YANG
1
;
Ning TAN
;
Peng-Cheng HE
;
Yong LIU
;
Jian-Yi WEN
;
Ji-Yan CHEN
;
Ying-Ling ZHOU
;
Wen-Hui HUANG
Author Information
1. 广东省心血管病研究所广东省人民医院
- Keywords:
Coronary disease;
Platelet activation;
Platelet-leukocyte aggregates
- From:
Chinese Journal of Cardiology
2012;40(6):482-486
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the platelet-leukocyte-aggregates (PLAs)level among patients with acute coronary syndrome (ACS) and stable angina pectoris (SAP).Methods Hospitalized patients were divided into three groups [ ACS group ( n =86 ),SAP group ( n =54 ),the control group with 46patients without coronary artery disease ].PLAs were measured by flow cytometry at admission before coronary angiography.ACS patients were further divided into low-risk group (0 - 108 points) and high-risk group ( ＞ 109 points ) according to GRACE scores at admission.PLA,platelet-monocyte aggregations ( PMA),platelet-neutrophile aggregations ( PNA ),platelet-lymphocyte aggregations ( PlyA ) and hs-CRP values were compared among groups.Results PLA (4.40％ ± 3.08％ ),PMA (33.6％ ± 21.5％ ),PNA(3.76％ ±5.06％),PLyA (2.03％ ± 1.27％) and hs-CRP [5.75(3.49,9.15)] levels in ACS group were significantly higher than those in SAP and control groups ( all P ＜ 0.05 ).PLA was also significantly higher in high-risk group than in the low-risk group (44.8％ ± 18.0％ vs.13.0％ ± 6.3％,P ＜ 0.01 ).Spearman correlation analysis showed that hs-CRP was positively correlated with PMA ( r =0.547,P ＜0.01 ) and GRACE score is positively correlated with PMA,PLA,PNA and PlyA ( r =0.746,0.652,0.460,respectively,all P＜0.01).Conclusion PLAs is increased in ACS patients and higher PMA level is related with the unstable coronary syndrome in ACS patients.Increased PMA,PLA,PNA and PlyA levels is associated with higher GRACE score in ACS patients.
