Studies on the chemical constituents from marine brown alga Ishige okamurai (3).
- Author:
Hai-feng TANG
1
;
Yang-hua YI
;
Xin-sheng YAO
;
Jiu-hong WU
;
Shu-yu ZHANG
;
Qiang-zhi XU
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Agents; isolation & purification; pharmacology; Female; Glycolipids; chemistry; isolation & purification; pharmacology; HL-60 Cells; drug effects; Humans; Mitosporic Fungi; drug effects; Molecular Structure; Phaeophyta; chemistry; Stearic Acids; chemistry; isolation & purification; Tumor Cells, Cultured
- From: China Journal of Chinese Materia Medica 2002;27(4):269-273
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the chemical constituents of Ishige okamurai.
METHODCompounds were isolated by Pyricularia oryzae bioassay-guided fractionation method in combination with extraction and partitionation as well as multi-chromatography. Their structures were determined by spectral analysis and chemical evidence.
RESULTSeven compounds were obtained and identified as (2S)-1-O-palmitoyl-2-O-(11Z-octadecenoyl)-3-O-beta-D-galacto-pyranosyl glycerol (I), (2S)-1-O-palmitoyl-2-O-myristoyl-3-O-(6-sulfo-alpha-D- quinovopyranosyl) glycerol (II), (2S)-1-O-palmitoyl-2-O-palmitoyl-3-O-(6'-sulfo-alpha-D- quinovopyranosyl) glycerol (III) and (2S)-1-O-palmitoyl-2-O-(11Z-octadecenoyl)-3-O-(6'-sulfo-alpha-D- quinovopyranosyl) glycerol (IV), stearic acid (V), methyl myristate(VI) and palmitic acid (VII).
CONCLUSIONCompounds I-VI were isolated from the alga for the first time while I, II and IV are new natural products. I-IV showed activity causing morphological abnormality of P. oryzae mycelia.
