Effects of epimedium total flavonoids phytosomes on preventing and treating bone-loss of ovariectomized rats.
- Author:
Yong-nan JIANG
1
;
Hong-ying MO
;
Ji-min CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Density; drug effects; Drug Carriers; Epimedium; chemistry; Estradiol; blood; Female; Flavonoids; administration & dosage; isolation & purification; pharmacology; Interleukin-6; blood; Osteoporosis; blood; drug therapy; prevention & control; Ovariectomy; Phospholipids; Phytotherapy; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2002;27(3):221-224
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effects of Epimedium total Flavonoids Phytosomes on preventing and treating bone-loss of the castrate osteoporosis rat model.
METHODThe osteoporosis model was established with 4-month-odl panther's rats, their ovaries on both sides castrated. Dual energy X-ray scanning was used to determine the bone density, and immunity and ELASA were used to assay concentration of estradiol and IL-6 in serum respectively, then determine their effect.
RESULTThe BMP and E2 of high dosage group nilestriol group and normal group are higher than those of model group (P < 0.01), while their content of IL-6 is apparently lower than that of model group(P < 0.01).
CONCLUSIONThe osteoporosis model was established successfully and the using of EFP can improve the bone density, enhance E2 level and decrease the IL-6 concentration in serum.
