Studies on the anti-inflammation effect of the TCM prescription of a combination of monkshood root with peony root.
- Author:
Hui-yun ZHANG
1
;
Lin QIN
;
Ling XUE
;
Shao-hua ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Aconitum; chemistry; Animals; Anti-Inflammatory Agents, Non-Steroidal; therapeutic use; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; therapeutic use; Edema; drug therapy; Female; Granuloma, Foreign-Body; drug therapy; Male; Mice; Paeonia; chemistry; Phytotherapy; Plant Roots; chemistry; Plants, Medicinal; chemistry; Rats
- From: China Journal of Chinese Materia Medica 2002;27(6):449-452
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo make a comparison between the single and combined use of Monkshood Root and Peony Root to observe the anti-inflammation effect in the experimental animals.
METHODThe experimental inflammatory models were adopted, i.e. adjuvant-induced polyarthritis carrageenan-induced or formaldehyde-induced rat paw edema, and cotton pellet-induced granuloma formation in rats xylene-induced mouse ear edema, exudation of abdominal blood capillaries of mice, etc.
RESULTThe anti-inflammafion effect of Monkshood Root was weaker than that of Peony Root or Peony Root combined with Monkshood Root. It was found that anti-inflammation effect with the drug-cooperation was enhanced more significantly in the formaldehyde-induced or adjuvant-induceed arthritis models than in the carrageenan-induced rat paw edema and other inflammatory models either in the large dosage of 1:1 proportion or in the small dosage of 1:2 proportion.
CONCLUSIONThe drug-cooperation has a good selective and synergic effect on anti-inflammation.
