Design of a three-dimensionally controlled multi-cell-assembly system based on the control of a mixer nozzle.
- Author:
Qiujun WANG
1
;
Mingen XU
;
Yanlei LI
;
Meijuan YUAN
;
Jinfu HU
Author Information
1. Institute of Biomedical Engineering and Instrument, Hangzhou Dianci University, Hangzhou 310018, China.
- Publication Type:Journal Article
- MeSH:
Bioartificial Organs;
Cell Culture Techniques;
instrumentation;
Cell Physiological Phenomena;
Equipment Design;
methods;
Extracellular Matrix;
chemistry;
Humans;
Tissue Engineering;
methods
- From:
Journal of Biomedical Engineering
2011;28(5):1030-1034
- CountryChina
- Language:Chinese
-
Abstract:
Three-dimensionally controlled cell-assembly technique makes fabricating tissues and organs in vitro to be possible. However, for real tissues and organs with complex structure and various cells, fabricating tissues and organs in vitro need a technique that could assemble and locate multi cells and materials precisely in the space. Facing the needs of multi-cell assembly, we designed a mixer nozzle and the matching pulse switching circuit which based on the single-nozzle cell assembly system, and developed a multi-cell-assembly system. We also carried out some assembly experiments with this system using materials that were similar to the multi-component extracellular matrix materials. The results demonstrated that the system could assemble various cells and materials into three-dimensional inhomogeneous structures precisely.
