The study of beta2-adrenergic receptor gene polymorphism in Sanda athletes.
- Author:
Ling CHEN
1
;
Chao SUN
;
Linhong DENG
Author Information
1. Bioengineering College, Chongqing University, Chongqing 400044, China.
- Publication Type:Journal Article
- MeSH:
Athletes;
China;
ethnology;
Gene Frequency;
Genotype;
Humans;
Male;
Polymorphism, Genetic;
genetics;
Receptors, Adrenergic, beta-2;
genetics;
Young Adult
- From:
Journal of Biomedical Engineering
2012;29(1):129-133
- CountryChina
- Language:Chinese
-
Abstract:
This study observed the disposition of beta2-adrenergic receptor (beta2-AR) Arg16Gly genotype and allele frequency among Sanda athletes in China, and investigated the diversity about the single nucleotide polymorphism of beta2-AR Arg16Gly between Sanda athletes and normal people of Han nationality in China. We used the technique of allele specified primer polymerase chain reaction to detect ADRB2 gene polymorphism of Sanda athletes (61 subjects) and normal Han nation people (50 subjects). The results showed there were significant differences about AA genotype, A allele, and G allele between Sanda athletes group and normal Han nation group (AA: chi2 = 6.646, P = 0.01, P < 0.05; A: chi2 = 4.003, P = 0.045, P < 0.05; G: chi2 = 4.003, P = 0.045, P < 0.05), and the frequency of AA genotype and A allele in the group of normal Han nation was higher than that in the group of Sanda athletes.
