Research on molecular mechanism of drug resistance of adefovir dipivoxil.
- Author:
Jie DAI
1
;
Hong TANG
Author Information
1. Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Adenine;
analogs & derivatives;
pharmacology;
Animals;
Antiviral Agents;
pharmacology;
Drug Resistance;
genetics;
Hepatitis B virus;
drug effects;
genetics;
Humans;
Mutation;
Organophosphonates;
pharmacology;
Reverse Transcriptase Inhibitors;
pharmacology
- From:
Journal of Biomedical Engineering
2012;29(1):184-187
- CountryChina
- Language:Chinese
-
Abstract:
Adefovir dipivoxil (ADV) is a nucleotide anti-hepatitis B virus drug, which is able to effectively repress the replication of hepatitis B virus (HBV). ADV is a reverse transcriptase inhibitor. However, with the prolonged period of using, many kinds of HBV genetic mutants will occur and therefore resistance to ADV will be created. The purpose of this review is to draw the attention to the molecular mechanism of resistance to ADV.
