Study of the interactions between diorganotin (IV) complexes of 1,3-dimethyl-4-acetyl-5-pyrazolone and mononucleotides and DNA.

Mei-ying Ning; Ting-fang LI; Qing-shan LI

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Study of the interactions between diorganotin (IV) complexes of 1,3-dimethyl-4-acetyl-5-pyrazolone and mononucleotides and DNA.

Author: Mei-ying NING ¹ ; Ting-fang LI ; Qing-shan LI
Author Information

1. School of Pharmaceutical Science, Shanxi Medical University, Third People's Hospital of Taiyuan, Taiyuan 030001, China.
Publication Type:Journal Article
MeSH: Antineoplastic Agents; chemistry; DNA; chemistry; Nucleotides; chemistry; Organotin Compounds; chemistry; Porphyrins; chemistry
From: Acta Pharmaceutica Sinica 2002;37(6):433-436
CountryChina
Language:Chinese
Abstract:
AIMThe interactions between diorganotin (IV) complexes of 1,3-dimethyl-4-acetyl-5-pyrazolone (HL1) and mono-nucleotides together with DNA near physiological condition were investigated.
METHODSThe mode of action of the diorganotin (IV) complexes with mononucleotides and DNA under different conditions and different times were investigated by high resolution NMR technology and UV spectra.
RESULTSThe interaction of [(L1)2SnEt2] with AMP was shown to result in significant change of chemical shift of H(8), H(2) and 31P of AMP. Hyperchromic effect of DNA could be observed due to the interaction of; [(L1)2SnEt2] with DNA, while interaction of [(L1)2SnMe2] with AMP and DNA could only cause obvious change of chemical shift of 31P and lead to hypochromic effect of DNA.
CONCLUSIONThe results indicate that [(L1)2SnEt2] can selectively bind to the N1 atom of the base and the phosphate oxygen atom of AMP and may further destroy the helical structure of DNA, while the dimethyltin (IV) compound of 1,3-dimethyl-4-acetyl-5-pyrazolone [(L1)2SnMe2] merely binds to the the phosphate oxygen atom of AMP and causes the contraction of DNA helical structure.