Studies on the chemical constituents of Lycianthes biflora.
- Author:
Guang-zhong YANG
1
;
Song ZHAO
;
Yuan-chao LI
Author Information
- Publication Type:Journal Article
- MeSH: 4-Butyrolactone; analogs & derivatives; chemistry; isolation & purification; Animals; Antineoplastic Agents, Phytogenic; chemistry; isolation & purification; Cinnamates; chemistry; isolation & purification; Leukemia P388; pathology; Mice; Molecular Structure; Plants, Medicinal; chemistry; Solanaceae; chemistry; Tumor Cells, Cultured; Tyramine; analogs & derivatives; chemistry; isolation & purification
- From: Acta Pharmaceutica Sinica 2002;37(6):437-439
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the chemical constituents of Lycianthes biflora.
METHODSColumn chromatography was used to separate the chemical constituents. IR, MS, 1HNMR, 13CNMR and 2D-NMR technique were used to determine the structures of the isolated constituents.
RESULTSFive compounds were isolated from this plant. Their structures were identified to be bifloride A (1), N-trans-cinnamoyltyramine (2), liquiritigenin (3), N-trans-p-coumaroyloctopamine (4), 1-O-beta-D-glucopyranosyl-2-N-2'-hydroxypalmitoyl-sphinga-4- trans-8-trans-dienine (5).
CONCLUSIONCompounds 1 and 2 are new compounds, the others were isolated from this plant for the first time. Compound 2 showed inhibitory effects on P-388.
