Electrochemical behavior of dopamine at the poly (isonicotinic acid) modified glassy carbon electrode.

Author: Hong ZHAO ¹ ; Yu-zhong ZHANG ; Zhuo-bin YUAN
Author Information

1. Department of Chemistry, Graduate School, University of Science and Technology of China, Academia Sinica, Beijing 100039, China. sh_zhaohong@sina.com.cn
Publication Type:Journal Article
MeSH: Ascorbic Acid; analysis; Dopamine; analysis; Electrochemistry; methods; Electrodes; Isonicotinic Acids; chemistry
From: Acta Pharmaceutica Sinica 2002;37(6):454-457
CountryChina
Language:Chinese
Abstract:
AIMTo study the determination of dopamine (DA) in the presence of ascorbic acid (AA) using poly (isonicotinic acid) film modified electrode.
METHODSThe cyclic voltammetry and differential pulse voltammetry were used to study the electrochemical behavior of DA at the poly (isonicotinic acid) film modified electrode.
RESULTSThe poly (isonicotinic acid) film modified electrode showed an electrocatalytic effect on DA, and shifted the oxidation of AA to negative potential. The difference between the oxidation potentials of DA and AA was 204 mV, thus, AA did not interfere with the determination of DA. The linear range between the anodic currents and DA concentration was: 1.0 x 10(-7)-2.0 x 10(-5) and 2.0 x 10(-5)-1.0 x 10(-4) mol.L-1. The detection limit was 8.0 x 10(-9) mol.L-1.
CONCLUSIONThe useful life period of the modified electrode is three weeks at least. The modified electrode can be used to the determination of DA in the sample.