The anticancer effect of artesunate and its mechanism.
- Author:
Qin WANG
1
;
Li-mao WU
;
Yi ZHAO
;
Xi-liu ZHANG
;
Nai-ping WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antineoplastic Agents, Phytogenic; therapeutic use; Apoptosis; Artemisinins; therapeutic use; Disease Models, Animal; Female; Gene Expression; Hepatocytes; metabolism; pathology; Liver Neoplasms, Experimental; drug therapy; metabolism; pathology; Male; Mice; Neoplasm Transplantation; Proliferating Cell Nuclear Antigen; biosynthesis; Proto-Oncogene Proteins; biosynthesis; Proto-Oncogene Proteins c-bcl-2; biosynthesis; Random Allocation; Sesquiterpenes; therapeutic use; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; bcl-2-Associated X Protein
- From: Acta Pharmaceutica Sinica 2002;37(6):477-478
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the anticancer effect of artesunate and its mechanism.
METHODSTo observe the effect of artesunate on the growth of solid tumor and the expression of PCNA, Bcl-2 and Bax genes in mice bearing H22 solid hepatic carcinoma.
RESULTSAfter administration of artesunate (ig, 300 mg.kg-1.d-1 x 7 d), growth of solid tumor was obviously inhibited, the tumor inhibitory rates were 49.1%, 48.7% and 46.6% and 46.6% in 3 experiments. The apoptosis of liver cancer cells were increased. Immunohistochemical staining showed that the number of Bcl-2 protein positive cells were decreased, but the number of Bax protein positive cells were increased. The PCNA positive cells were significantly lower than those in the control group.
CONCLUSIONArtesunate showed obvious anticancer activity on H22 hepatic carcinoma bearing mice and undergo apoptosis of liver cancer cells. The mechanism of anticancer effect of artesunate may be related to down-regulation of the expression of PCNA and Bcl-2 genes and up-regulation of the expression of Bax gene.
