Experimental studies on the anti-thrombosis effect of 3,4-oxo-isopropylidene-shikimic acid.
- Author:
Hong-tao WANG
1
;
Hong-tao JIN
;
Jian-ning SUN
;
Qiu-ping XU
;
Ya-jian GUO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain; pathology; Disease Models, Animal; Fibrinolytic Agents; pharmacology; therapeutic use; Infarction, Middle Cerebral Artery; blood; pathology; prevention & control; Male; Platelet Aggregation; drug effects; Rabbits; Random Allocation; Rats; Rats, Wistar; Shikimic Acid; analogs & derivatives; chemistry; isolation & purification
- From: Acta Pharmaceutica Sinica 2002;37(4):245-248
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the effect of 3,4-oxo-isopropylidene-shikimic acid (ISA) against arteriovenous shunt and middle cerebral artery thrombosis (MCAT) in rats.
METHODSArteriovenous shunt model was adopted to measure thrombus weight; The neurologic deficit (ND) and the infarct size (IS) of the middle cerebral thrombosis (MCAT) model induced by FeCl3 were observed; The effect of ISA on platelet aggregation rate of rat and rabbit by giving ISA in vivo and in vitro was studied.
RESULTSISA 25, 50, 100 and 200 mg.kg-1 ig was shown to reduced the weight of thrombus in arteriovenous shunt model; ISA 50, 100 and 200 mg.kg-1 ig for 2 times in 24 hours, attenuated the ND of rats subjected to MCAT; ISA 100 and 200 mg.kg-1 reduced IS of rats after MCAT by 27.8% and 31.6%, respectively; ISA 50, 100 and 200 mg.kg-1 ig inhibited platelet aggregation of normal rats; ISA 10(-3)-10(-5) mol.L-1, inhibited rabbit platelet aggregation in vitro.
CONCLUSIONISA inhibited thrombosis by anti-platelet-aggregation.
