Approach to the crystalline characteristics of ceftezole sodium.
- Author:
Chang-qin HU
1
;
Shuang-hong CHENG
;
Lu LU
Author Information
- Publication Type:Journal Article
- MeSH: Cefazolin; analogs & derivatives; chemistry; classification; Crystallization; Crystallography, X-Ray; Drug Stability; Molecular Conformation; Molecular Structure
- From: Acta Pharmaceutica Sinica 2002;37(4):275-279
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the crystalline characteristics of ceftezole sodium.
METHODSCeftezole sodium crystals were obtained from different solvents. X-ray diffraction, DSC, TGA, etc were used to analyze the crytals.
RESULTSCeftezole sodium crystal was easily obtained in isopropanol-water mixture. It consists of ceftizole sodium monohydrate, which consists of type I and type II two different crystal forms. Powder X-ray diffraction patterns showed differences between type I and the type II crystal forms. Peaks at 8 degrees and 18 degrees in diffractograms of the type I, but at 9 degrees and 18.6 degrees in the type II could be observed. Water molecules in different crystal forms had different combining condition. They lost during 35-117 degrees C in the type I form, but lost during 110-160 degrees C in the type II form.
CONCLUSIONStructure of ceftizole sodium monohydrate crystal obtained in different circumstance could be some vary, which influence upon the thermal stability of the compound. The type I crystal form is more stable than the type II.
