Effect of Preventive Nicardipine on Hemodynamics Induced by Pneumoperitoneum during Laparoscopic Cholecystectomy.
10.4097/kjae.2005.49.3.327
- Author:
Jae Hoon JEONG
1
;
Dong Gun LIM
Author Information
1. Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Daegu, Korea. dglim@knu.ac.kr
- Publication Type:Original Article
- Keywords:
cholecystectomy;
hemodynamics;
laparoscopy;
nicardipine;
pneumoperitoneum
- MeSH:
Blood Pressure;
Cardiac Output;
Cholecystectomy;
Cholecystectomy, Laparoscopic*;
Heart Rate;
Hemodynamics*;
Humans;
Insufflation;
Intubation, Intratracheal;
Laparoscopy;
Nicardipine*;
Pneumoperitoneum*;
Skin;
Vascular Resistance
- From:Korean Journal of Anesthesiology
2005;49(3):327-331
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Pneumoperitoneum for a laparoscopic cholecystectomy induces hemodynamic changes. The present study investigated the effect of preventive nicardipine on the hemodynamics induced by pneumoperitoneum during a laparoscopic cholecystectomy. METHODS: Forty five patients, scheduled to undergo laparoscopic cholecystectomy, were selected, and divided into three groups; the control group (C; normal saline infusion), the nicardipine bolus injection group (NB; 20microgram/kg nicardipine infusion, 1 min before skin incision) and the nicardipine continuous infusion group (NI; 2microgram/kg/min continuous infusion, from the time of endotracheal intubation to pneumoperitoneum). The blood pressure, heart rate, cardiac output and systemic vascular resistance were measured; at preincision, and at 5, 10 and 15 min after insufflation and at 5 min after exsufflation. RESULTS: Nicardipine injection attenuated increases in the blood pressure, systemic vascular resistance after pneumoperitoneum, and didn't attenuate decrease in the cardiac output. CONCLUSIONS: A preventive nicardipine injection is effective in attenuating the hemodynamic change after pneumoperitoneum during a laparoscopic cholecystectomy, especially attenuated the systemic vascular resistance and blood pressure increase.
