A new monoterpenoid glucoside from the twigs of Chamaecyparis obtusa var. breviramea f. crippsii.
- Author:
Jian XU
1
;
Yu-Mei ZHANG
;
Ke-Li CHEN
;
Ning-Hua TAN
;
Yi-Mei LIU
Author Information
1. Key Laboratory of Ministry of Education for Traditional Chinese Medicine Resource and Compound Prescription, Hubei University of Chinese Medicine, Wuhan 430065, China.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents, Phytogenic;
chemistry;
isolation & purification;
pharmacology;
Cell Line, Tumor;
Chamaecyparis;
chemistry;
Coumarins;
chemistry;
isolation & purification;
pharmacology;
Glucosides;
chemistry;
isolation & purification;
pharmacology;
Humans;
Molecular Structure;
Monoterpenes;
chemistry;
isolation & purification;
pharmacology;
Plant Leaves;
chemistry;
Plant Stems;
chemistry;
Plants, Medicinal;
chemistry;
Stigmasterol;
analogs & derivatives;
chemistry;
isolation & purification;
pharmacology
- From:
Acta Pharmaceutica Sinica
2012;47(9):1179-1182
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the chemical constituents of Chamaecyparis obtusa var. breviramea f. crippsii, various column chromatography and spectroscopic methods were used for the isolation and elucidation of compounds. One new monoterpenoid glucoside, (4S)-4-isopropylcyclohex-l-enecarboxylic acid 4-O-beta-D-glucopyranoside (1), together with five known compounds, (4R)-p-menth-l-ene-7, 8-diol 7-O-beta-D-glucopyranoside (2), skimmin (3), 7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2H-1-benzopyran-2-one (4), stigmast-4-en-3-one (5) and 1, 4-benzenedicarboxylic acid 1-butyl-4-(2-methylpropyl) ester (6) were isolated and identified from the twigs of this plant. All compounds were isolated from this plant for the first time. The methanol extract of this plant showed cytotoxicity on cancer cell lines A549, BGC-823, Du145 and MDA-MB-231 with IC50 values of 0.94, 1.07, 0.95 and 0.96 microg x mL(-1), respectively. Yet, compounds 1, 2 and 3 showed no cytotoxicity on cancer cell lines HeLa, BGC-823 and A549.
