Screening of bioactive components in epimedium for osteoporosis treatment by model population analysis.
- Author:
Qian-Xu YANG
1
;
Yan-Qiu LIU
;
Li WANG
;
Hong-Bin XIAO
Author Information
1. Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
- Publication Type:Journal Article
- MeSH:
Cell Proliferation;
drug effects;
Cytological Techniques;
methods;
Drugs, Chinese Herbal;
isolation & purification;
pharmacology;
Epimedium;
chemistry;
Flavonoids;
isolation & purification;
pharmacology;
Humans;
Osteoclasts;
cytology;
Plants, Medicinal;
chemistry
- From:
Acta Pharmaceutica Sinica
2012;47(9):1205-1209
- CountryChina
- Language:Chinese
-
Abstract:
Epimedium was obtained from different habitats, and their bioactive components for inhibiting RAW264.7 were screened by MTT assay. Results indicate that epimedium from different habitats displayed significant different activities. By means of model population analysis (MPA), a latent bioactive component, baohuoside-I was got. Activity of baohuoside-I wasvalidated and prior to icariin. MPA can be used for bioactive components screening.
