The preparation and kinetic study on enzymatically-controlled drug release of isotretinoin/amylose inclusion complex.
- Author:
Qi-Fang WANG
1
;
San-Ming LI
;
Tian-Hong ZHANG
;
Jing YU
;
Zhong-Sheng HU
;
Yue LI
Author Information
1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. oshwang@sina.com
- Publication Type:Journal Article
- MeSH:
Amylose;
chemistry;
Calorimetry, Differential Scanning;
Dermatologic Agents;
chemistry;
Drug Carriers;
chemistry;
Hydrolysis;
Isotretinoin;
chemistry;
Kinetics;
Temperature;
X-Ray Diffraction;
alpha-Amylases;
chemistry
- From:
Acta Pharmaceutica Sinica
2012;47(9):1227-1230
- CountryChina
- Language:Chinese
-
Abstract:
The inclusion complex of isotretinoin was prepared by sealed-control temperature method and amylose was used as carrier. The formation of inclusion complex was confirmed by powder X-ray diffraction and DSC. The equation of enzymatically-controlled drug release was established by kinetic theory, and the release characteristic of drug was confirmed by using the kinetic equation. The results show that the drug release was attributed to first order reaction without alpha-amylase. However, with alpha-amylase, the drug release was an acceleration process by the effect of both dissociation and enzymatic hydrolysis simultaneously. The research indicates that drug release from the inclusion complex was modulated by the addition of alpha-amylase.
