TREK1 potassium channels and depression.
- Author:
Dong-Qing YE
1
;
Zhi-Jun ZHANG
;
Yang LI
Author Information
1. Institute of Neurology and Psychiatry, Southeast University, Nanjing 210009, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antidepressive Agents;
pharmacology;
Depressive Disorder, Major;
genetics;
metabolism;
physiopathology;
Drug Delivery Systems;
Gene Knockout Techniques;
Humans;
Neuronal Plasticity;
Polymorphism, Genetic;
Potassium Channels, Tandem Pore Domain;
genetics;
metabolism;
physiology;
Receptors, Serotonin;
metabolism;
Receptors, Serotonin, 5-HT4;
Serotonin;
pharmacology
- From:
Acta Pharmaceutica Sinica
2012;47(11):1403-1408
- CountryChina
- Language:Chinese
-
Abstract:
Major depression disorder is an increasing heavy burden in modem society, but its pathological mechanism is still vague. Recent evidence indicated that two pore potassium channel, TREK1, is one of the important drug targets of antidepressants. The structural and functional research progress of TREK1 potassium channel were reviewed with an emphasis on its roles in anti-depression, neuronal protection, and neuronal plasticity. The complicated interactions between TREK1 potassium channel and monoamine transmitters-receptors were also reviewed and future directions to explore the underline mechanism were also discussed.
