Identification of metabolites of arbidol by ultra-high performance liquid chromatography tandem mass spectrometry.
- Author:
Xiao LIU
1
;
Huan LI
;
Kai-Shun BI
;
Xiao-Hui CHEN
;
Hao CAI
;
Bao-Chang CAI
Author Information
1. College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Biotransformation;
Chromatography, High Pressure Liquid;
Feces;
chemistry;
Female;
Indoles;
blood;
metabolism;
pharmacokinetics;
urine;
Male;
Rats;
Rats, Wistar;
Tandem Mass Spectrometry
- From:
Acta Pharmaceutica Sinica
2012;47(11):1521-1526
- CountryChina
- Language:Chinese
-
Abstract:
UPLC-MS-MS system was used for the identification of arbidol metabolites in the rat feces, urine and plasma samples. The system was so powerful a way with high ability of separation and analysis, based on both chromatography and mass properties. The isotope of Br was also a good indicator for metabolites finding. There were altogether 9 metabolites detected and identified, including 2 phase I biotransformation products and 7 phase II ones. It is concluded that arbidol mainly undergo metabolic reactions such as N-demethylation, S-oxidation, glucuronidation and sulfation in rats.
