Silica-coated ethosome as a novel oral delivery system for enhanced oral bioavailability of curcumin.
- Author:
Chong LI
1
;
Li DENG
;
Yan ZHANG
;
Ting-Ting SU
;
Yin JIANG
;
Zhang-Bao CHEN
Author Information
1. College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China. chongli2009@gmail.com
- Publication Type:Journal Article
- MeSH:
Administration, Oral;
Animals;
Biological Availability;
Coated Materials, Biocompatible;
chemistry;
Curcumin;
administration & dosage;
chemistry;
pharmacokinetics;
Drug Carriers;
Ethanol;
chemistry;
Liposomes;
chemistry;
Male;
Particle Size;
Rats;
Rats, Sprague-Dawley;
Silicon Dioxide;
chemistry;
Solubility
- From:
Acta Pharmaceutica Sinica
2012;47(11):1541-1547
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study is to investigate the feasibility of silica-coated ethosome as a novel oral delivery system for the poorly water-soluble curcumin (as a model drug). The silica-coated ethosomes loading curcumin (CU-SE) were prepared by alcohol injection method with homogenization, followed by the precipitation of silica by sol-gel process. The physical and chemical features of CU-SEs, and curcumin release were determined in vitro. The pharmacodynamics and bioavailability measurements were sequentially performed. The mean diameter of CU-SE was (478.5 +/- 80.3) nm and the polydispersity index was 0.285 +/- 0.042, while the mean value of apparent drug entrapment efficiency was 80.77%. In vitro assays demonstrated that CU-SEs were significantly stable with improved release properties when compared with curcumin-loaded ethosomes (CU-ETs) without silica-coatings. The bioavailability of CU-SEs and CU-ETs was 11.86- and 5.25-fold higher, respectively, than that of curcumin suspensions (CU-SUs) in in vivo assays. The silica coatings significantly promoted the stability of ethosomes and CU-SEs exhibited 2.26-fold increase in bioavailablity relative to CU-ETs, indicating that the silica-coated ethosomes might be a potential approach for oral delivery of poorly water-soluble drugs especially the active ingredients of traditional Chinese medicine with improved bioavailability.
