Research progress of self-assembled beads drug delivery system prepared from cyclodextrins and oils.
- Author:
Chuan LIU
1
;
Tao YI
Author Information
1. School of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
- Publication Type:Journal Article
- MeSH:
Administration, Oral;
Animals;
Biological Availability;
Drug Carriers;
Drug Delivery Systems;
Particle Size;
Solubility;
Soybean Oil;
administration & dosage;
chemistry;
pharmacokinetics;
alpha-Cyclodextrins;
administration & dosage;
chemistry;
pharmacokinetics
- From:
Acta Pharmaceutica Sinica
2012;47(12):1582-1586
- CountryChina
- Language:Chinese
-
Abstract:
Recently, increasing attention has been paid to beads, an innovative self-assembled drug delivery system prepared from cyclodextrins and oils. Beads are new core-shell minispheres containing poorly water-soluble drugs or lipophilic drugs dissolved in the lipid core without the use of organic solvents and surfactants. Therefore, beads with high drug loading and improved oral bioavailability have great potential for oral delivery of poorly water-soluble drugs and lipophilic drugs. The preparation mechanisms, formulations and methods, the in vitro and in vivo properties of beads were reviewed in order to provide the theoretical basis for further application of beads.
