Enhanced bioavailability of total paeony glycoside by self-microemulsifying drug delivery system.
- Author:
Li-Jiang CHEN
1
;
Yang LIU
;
Yu LIU
;
Li LI
;
Fei GAO
Author Information
1. College of Pharmaceutical Sciences, Liaoning University, Shenyang 110036, China. chlj16@163.com
- Publication Type:Journal Article
- MeSH:
Administration, Oral;
Animals;
Biological Availability;
Drug Delivery Systems;
Drug Stability;
Emulsions;
Ethylene Glycols;
chemistry;
Glycosides;
administration & dosage;
chemistry;
isolation & purification;
pharmacokinetics;
Oleic Acids;
chemistry;
Paeonia;
chemistry;
Particle Size;
Pharmaceutical Vehicles;
chemistry;
Plants, Medicinal;
chemistry;
Polyethylene Glycols;
chemistry;
Rats;
Solubility
- From:
Acta Pharmaceutica Sinica
2012;47(12):1678-1686
- CountryChina
- Language:English
-
Abstract:
Total paeony glycoside (TPG) is extracted and purified from a traditional Chinese herbal medicine. It has many biological and pharmacological activities. However, there are few dosage forms of TPG in the market because of its low bioavailability. Self-microemulsifying drug delivery system (SMEDDS) is a vital tool in solving low bioavailability of poor absorption drugs. So the objective of this study is to develop a new TPG-SMEDDS for the oral delivery of poorly soluble TPG. Through the construction of pseudo-ternary phase diagrams, the optimum prescription was obtained, which consisted of 18.70% TPG, 16.27% ethyl oleate as oil, 43.34% Cremophor RH40 as surfactant and 21.73% Transcutol P as cosurfactant. The characterizations of TPG-SMEDDS including morphological characterization, droplet size, zeta-potential, emulsification time, and dissolution study of TPG-SMEDDS were evaluated. The results showed that TPG-SMEDDS is stable and its release rate is high in four different media (0.1 mol x L(-1) HCl, pH 6.8 PBS, pH 7.4 PBS, and water). The relative bioavailability of SMEDDS was dramatically enhanced in an average of 1.52-fold that of TPG-suspension. It is concluded that the bioavailability of TPG is enhanced greatly by SMEDDS.
