Effects on the pharmacokinetics of furosemide after acute exposure to high altitude at 4010 meters in rats.
- Author:
Wen-Bin LI
1
;
Rong WANG
;
Hua XIE
;
Juan-Hong ZHANG
;
Xi-Hui XIE
;
Xiao-Yu WU
;
Zheng-Ping JIA
Author Information
1. Key Laboratory of the Plateau of the Environmental Damage Control, General Hospital of Lanzhou Military Command, PLA, Lanzhou 730050, China.
- Publication Type:Journal Article
- MeSH:
Administration, Oral;
Altitude;
Animals;
Area Under Curve;
Chromatography, Liquid;
Furosemide;
administration & dosage;
metabolism;
pharmacokinetics;
Half-Life;
Male;
Rats;
Rats, Wistar;
Spectrometry, Mass, Electrospray Ionization;
Tandem Mass Spectrometry
- From:
Acta Pharmaceutica Sinica
2012;47(12):1718-1721
- CountryChina
- Language:Chinese
-
Abstract:
The paper is to report the pharmacokinetics of furosemide in rats living at plain area and high altitude. After intragastric administration of furosemide (2.87 mg x kg(-1)), serial blood samples (0.5 mL) were collected by retro-orbital puncture at 0, 20 min, 40 min, 1, 1.5, 2, 3, 4, 6, 8, 12 and 24 h, samples were determined by LC-MS/MS, and plasma concentration-time data were analyzed by DAS 2.0 software to get the related pharmacokinetic parameters. The main pharmacokinetic parameters: area under curve (AUC), mean residence time (MRT), the biological half-life (t1/2) and the peak concentration (C(max)) of furosemide, were significantly increased at high altitude, the time to reach peak concentration (t(max)) and clearance (CL) was significantly decreased. This study found significant changes on the pharmacokinetics of furosemide under the special environment of high altitude. This finding may provide some references for clinical rational application of furosemide at high altitude.
