Progress in the fragment-based drug discovery.
- Author:
Jing REN
1
;
Jian LI
;
Feng SHI
;
Xin WANG
;
Jian-Hua HE
;
Ye-Chun XU
;
Nai-Xia ZHANG
;
Bing XIONG
;
Jing-Kang SHEN
Author Information
1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
- Publication Type:Journal Article
- MeSH:
Computer-Aided Design;
Crystallography, X-Ray;
Drug Discovery;
methods;
Ligands;
Magnetic Resonance Spectroscopy;
Peptide Fragments;
chemical synthesis;
chemistry;
Protein Conformation;
Small Molecule Libraries;
Surface Plasmon Resonance
- From:
Acta Pharmaceutica Sinica
2013;48(1):14-24
- CountryChina
- Language:Chinese
-
Abstract:
As an extension of the structure-based drug discovery, fragment-based drug discovery is matured increasingly, and plays an important role in drug development. Fragments in a small library, with lower molecular mass and high "ligand efficiency", are detected by SPR, MS, NMR, X-ray crystallography technologies and other biophysical methods. Then they are considered as starting points for chemical optimization with the guidance of structural biology methods to get good "drug-like" lead and candidate compounds. In this article, we reviewed the current progress of fragment-based drug discovery and detailed a number of examples to illustrate the novel strategies.
