Expression of marray serine proteinase inhibitor in oral squamous cell carcinoma and its clinical significance
10.3760/cma.j.issn.1002-0098.2009.10.008
- VernacularTitle:乳腺丝氨酸蛋白酶抑制剂在口腔鳞状细胞癌中的表达及意义
- Author:
Jun LUO
1
;
Lan ZHOU
;
Gen-Jian ZHENG
;
Tong JI
;
Lai-Ping ZHONG
Author Information
1. 浙江省台州市中心医院
- Keywords:
Carcinoma;
squamous cell;
Serine proteinase inhibitors;
Prognosis
- From:
Chinese Journal of Stomatology
2009;44(10):606-610
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of marray serine proteinase inhibitor(Maspin)in patients with oral squamous cell carcinoma and its relationship with clinicopathological features.Methods The Maspin protein expression was examined in 45 patients with oral squamous cell carcinoma and in non malignant oral epithelia by immunohistochemical staining.The relationship between the Maspin protein expression and the clinicopathological parameters was statistically analyzed. Results The Maspin protein expression in the cancerous tissues of oral squamous cell carcinoma was lower than that in the non-malignant oral epithelia(P=0.001). Negative correlation was found between the Maspin protein expression in cancerous tissue and the status of lymph node metastasis(P=0.038).Positive Maspin protein expression indicated negative lymph node metastasis,and negative correlation was also found between the Maspin protein expression and the postoperative metastasis(P=0.004).Positive correlation was found between the Maspin expression and the patients'survival rate(P=0.014),patients with positive Maspin protein expression having hisher survival rate than those with negative Maspin expression.Conclusions Maspin might be useful as a potential prognostic marker for oral squamous cell carcinoma.
