Advances in researches on genetic predisposition to steroid-induced osteonecrosis of the femoral head.
- Author:
Ping ZENG
1
;
Biao-fang WEI
;
Wei HE
;
Shi-bing SU
Author Information
1. Department of Orthopaedics, the 1st Affiliated Hospital of Guangzhou University of TCM, Guangzhou 510405, Guangdong, China.
- Publication Type:Journal Article
- MeSH:
ATP Binding Cassette Transporter, Sub-Family B;
ATP-Binding Cassette, Sub-Family B, Member 1;
genetics;
Cytochrome P-450 CYP3A;
genetics;
Femur Head Necrosis;
chemically induced;
genetics;
Genetic Predisposition to Disease;
Glucocorticoids;
adverse effects;
Humans;
Lipid Metabolism;
Polymorphism, Single Nucleotide;
Receptors, Glucocorticoid;
genetics
- From:
China Journal of Orthopaedics and Traumatology
2010;23(2):156-159
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of steroid-induced osteonecrosis of the femoral head (SONFH) is not very clear at present. For the past few years researches showed that the SONFH related to genetic predisposing factors. The related research progresses were reviewed in this article to show the correlation between genetic mutation and genetic polymorphism of steroid metabolism and transport, resistance and receptor, coagulation and fibrinolysis, lipid and bone metabolism and susceptibility to SONFH. The article also discussed current problems, countermeasure and future applications.
