Immunoresponse after immunization of Hepatitis B virus in medical students
- Author:
Chi Huu Nguyen
- Publication Type:Journal Article
- Keywords:
Hepatitis B
- MeSH:
Hepatitis B;
Vaccination
- From:Journal of Practical Medicine
2002;430(9):37-39
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
From May to December 1999, we performed a study to look for the antibody response after vaccination against hepatitis B in 112-second year medical students (97, Faculty of Medicine, Ho Chi Minh city, VietNam). We used recombinant DNA vaccine (HB VAX- II, MSD), with standard schedule (0,16 months). The healthy students (mean age: 19,7+/- 1,5 mean height 1,6+/- 0,1 m, mean body weight 51,1+/- 6,6 kg) who had neither immunodepression nor previous hepatitis B vaccination were included in this study. The sera from these were negative for HBsAg anti-HBs, anti-HBc. The good immunological response after vaccination was confirmed by the level of anti-HBs >10 m Ul/ml in the sera (blood taken 1 month after the 3rd injection). The results were encouraging: 100% students who received the vaccine got a good response with the height level of anti- HBs in the sera (average: 794+/- 306mU/ml). The level of anti-HBs was below <100mUI/ml in 2 students (1.8%), 100-< 500 in 20(17.8%),500-<1000 in 20 (17.8%) and >= 1000 in 70 (62,5%). These students had no close relationship with the age and the sex.
