Comparative study on pharmacokinetics of six major alkaloids in Zuojin Wan microemulsion based gel and hydrogel.
- Author:
Long CHENG
1
;
Yanli WANG
;
Shuzhi LIU
;
Lan WANG
;
Hong YI
;
Maobo DU
;
Hua YANG
;
Rixin LIANG
;
Xiaojie YIN
Author Information
- Publication Type:Journal Article
- MeSH: Alkaloids; administration & dosage; chemistry; pharmacokinetics; Animals; Chromatography, Liquid; Drug Delivery Systems; Drugs, Chinese Herbal; administration & dosage; chemistry; pharmacokinetics; Emulsions; Female; Gels; Hydrogels; chemistry; Male; Mass Spectrometry; Rats
- From: China Journal of Chinese Materia Medica 2011;36(23):3327-3331
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the pharmcoknetic parameters of six major alkaloids in the two drug delivery system of Zuojin Wan, by LC-MS assaying the six major alkaloids plasma concentration.
METHODThe blood samples were collected at different time after transdermal administration. The plasma concentration of six major alkaloids were detected by LC-MS, then the concentration-time data are modulated by software WinNonlin.
RESULTTook the six alkaloids (berberine palmatine coptisine jateorhizine evodiamine rutecarpine) as index components, the relative bioavailability were 131%, 127%, 108%, 121%, 92%, 109%, respectively, the ratio of Ka were 10.5, 5.1, 3.7, 0.8, 1.8, 1.5, respectively.
CONCLUSIONThe LC-MS can be applied in the determination of six major alkaloids plasma concentration. The pharmcoknetic parameters indicated that Zuojin Wan microemulsion gel delivery system can accelerate the transdermal absorption rate of Zuojin Wan, compared with the hydrogel drug delivery system.
