Effects of Tiangou Jiangya capsule on hypertension and hemodynamics in anaesthetized dogs.
- Author:
Yujie LI
1
;
Qing YANG
;
Xiaogang WENG
;
Ying CHEN
;
Shuyuan ZHOU
;
Dan LI
;
Xiaoxin ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antihypertensive Agents; administration & dosage; pharmacology; therapeutic use; Benzyl Alcohols; pharmacology; therapeutic use; Blood Pressure; drug effects; Disease Models, Animal; Dogs; Drugs, Chinese Herbal; administration & dosage; pharmacology; therapeutic use; Female; Flavonoids; pharmacology; therapeutic use; Furans; pharmacology; therapeutic use; Glucosides; pharmacology; therapeutic use; Heart Rate; drug effects; Hemodynamics; drug effects; Hypertension; drug therapy; Lignans; pharmacology; therapeutic use; Male; Oxygen Consumption; drug effects; Vascular Resistance; drug effects
- From: China Journal of Chinese Materia Medica 2011;36(23):3338-3343
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effects of Tiangou Jiangya capsule on blood pressure and hemodynamics in anesthetized Beagle dogs.
METHODAnesthetized dogs were divided into five groups: Tiangou Jiangya capsule 3-dose groups as 1.6, 3.2, 6.4 g x kg(-1), positive control group was giving captopril, negative control was giving 0.5% CMC-Na, duodenal administration. The blood pressure and hemodynamic changes were observed.
RESULTThe systolic blood pressure of middle-dose Tiangou Jiangya capsule group was significantly reduced at 30 min after administration. The systolic blood pressure (SAP) and diastolic blood pressure (DAP) of high-dose group of Tiangou Jiangya capsule was significantly reduced at 15 min to 90 min after administration. High-dose Tiangou Jiangya capsule can also significantly reduce cardiac work (LVW) and total peripheral resistance (TPR). Tiangou Jiangya capsule had no significant effect on the other hemodynamic parameters and myocardial oxygen consumption.
CONCLUSIONTiangou Jiangya capsule has a significant effect on reducing blood pressure, which is related to the reducing total peripheral resistance and reducing cardiac work. The result can provide a reference to further clarify the Tiangou Jiangya capsule mechanism on reducing blood pressure.
