Influence of Tiangou Jiangya capsule on blood pressure in renovascular hypertension rats.
- Author:
Qing YANG
1
;
Yujie LI
;
Xiaoni LIU
;
Xiaogang WENG
;
Ying CHEN
;
Xiaoxin ZHU
;
Xiao HAN
;
Lijuan ZOU
;
Dan LI
Author Information
- Publication Type:Journal Article
- MeSH: Angiotensin II; blood; Animals; Antihypertensive Agents; administration & dosage; pharmacology; therapeutic use; Benzyl Alcohols; pharmacology; therapeutic use; Blood Pressure; drug effects; Drugs, Chinese Herbal; administration & dosage; pharmacology; therapeutic use; Flavonoids; pharmacology; therapeutic use; Furans; pharmacology; therapeutic use; Glucosides; pharmacology; therapeutic use; Hypertension, Renovascular; blood; drug therapy; Lignans; pharmacology; therapeutic use; Rats; Rats, Wistar; Renin; blood; Renin-Angiotensin System; drug effects
- From: China Journal of Chinese Materia Medica 2011;36(23):3344-3348
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of Tiangou Jiangya capsule (TJC) on blood pressure in renovascular hypertension rats and explore its possible mechanism.
METHODSeventy-two Wistar rats were randomly divided into normal control group, model group, captopril group, TJC small, medium and high dose groups. Non-invasive blood pressure measurement was used to detect the arterial blood pressure of rat tails. PRA, Ang II , ALD, 6-Keto-PGF1alpha, ET and TXB2 content in blood was measured by radioimmunoassay. NO content in blood was determined by method of nitrate reductase.
RESULTThe systolic, diastolic and mean pressure significantly increased, serum PRA, Ang II , ALD decreased, ET levels significantly increased in model group rats. TJC significantly reduced blood pressure, improved the plasma renin activity, decreased ET levels and increased NO content of model rats.
CONCLUSIONTJC can reduce blood pressure of renovascular hypertention rats, and the mechanism may be related to its regulating lower blood pressure regulation of the secretion of RAAS system and improving vascular endothelial function.
