Effects of Tiangou Jiangya capsule on blood pressure in spontaneous hypertensive rat.
- Author:
Yujie LI
1
;
Qing YANG
;
Xiaogang WENG
;
Ying CHEN
;
Dan LI
;
Lijuan ZOU
;
Xiaoxin ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antihypertensive Agents; pharmacology; therapeutic use; Benzyl Alcohols; pharmacology; therapeutic use; Blood Pressure; drug effects; Disease Models, Animal; Diuresis; drug effects; Drugs, Chinese Herbal; pharmacology; therapeutic use; Flavonoids; pharmacology; therapeutic use; Furans; pharmacology; therapeutic use; Glucosides; pharmacology; therapeutic use; Heart Rate; drug effects; Hypertension; drug therapy; Lignans; pharmacology; therapeutic use; Male; Rats; Rats, Inbred SHR; Renin-Angiotensin System; drug effects; Ventricular Function, Left; drug effects
- From: China Journal of Chinese Materia Medica 2011;36(23):3353-3357
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of Tiangou Jiangya capsule on blood pressure of spontaneous hypertensive rats.
METHODThe 13-14 week SPF rats were selected and randomly divided into model groups, the low, middle, high dose of Tiangou Jiangya capsule groups, positive control group administrated with captopril. Drugs were intragastric administrated once per day, lasting four weeks. The blood pressure, heart rate, heart ventricle indexes, urinary volume and the level of PRA,angiotensing II (Ang II), aldosterone (ALD) of rats were observed.
RESULTThe low, middle, high dose of Tiangou Jiangya capsule can remarkably reduce the systolic pressure, diastolic pressure and mean arterial pressure of spontaneous hypertensive rats (P < 0.05 or P < 0.01). The low, middle dose can reduce the heart rate of rats (P < 0.01). The low dose can effectively inhibit the left ventricle indexes (P < 0.05). The Tiangou Jiangya capsule has no markedly effects on the renin-angiotensin-aldosterone system (RAAS) activity and urinary output of rats.
CONCLUSIONThe results indicate that the Tiangou Jiangya capsule has evident effect of lowering blood pressure of rats, which is related to reducing heart rate, heart ventricle indexes, and has no effect on the RAAS and diuresis.
