Analysis on changes of purgative biopotency in different processed products of rhubarb.
- Author:
Huifang LI
1
;
Jiabo WANG
;
Yi QU
;
Xiaohe XIAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cathartics; administration & dosage; pharmacology; Drugs, Chinese Herbal; administration & dosage; pharmacology; Male; Mice; Mice, Inbred ICR; Plant Extracts; administration & dosage; pharmacology; Rheum; chemistry; Senna Extract; pharmacology
- From: China Journal of Chinese Materia Medica 2012;37(3):302-304
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the difference on purgative biopotency of different processed products of rhubarb and compare rhubarb before and after preparation.
METHODThe prime biopotency of rhubarb reference substance was determined by comparing with the control substance of sennoside B using rat purgative model. Comparing with calibrated rhubarb reference substance, the bioactivity different processed products of rhubarb was determined by the 2,2',2" method.
RESULTThe purgative biopotency of crude rhubarb was 825.22 U x g(-1). The purgative biopotency of alcohol-processed rhubarb was 699.05 U x g(-1), The purgative biopotency of steamed rhubarb were 459.76 U x g(-1). Carbonized rhubarb cannot be determinate.
CONCLUSIONCrude rhubarb showed a significantly declineing purgative biopotency after being processed, alcohol-processed rhubarb showed less than crude rhubarb and followed by steamed rhubarb. Carbonized rhubarb lost almost all purgative bioactivity.
