Chemical constituents of Datura stramonium seeds.

Author: Jianwen LI ¹ ; Binbin LIN ; Guokai WANG ; Hongjie GAO ; Minjian QIN
Author Information

1. Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 211198, China.
Publication Type:Journal Article
MeSH: Datura stramonium; chemistry; Seeds; chemistry
From: China Journal of Chinese Materia Medica 2012;37(3):319-322
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo study chemical constituents in the seeds of Datura Stramonium (Solanaceae family).
METHODCompounds were isolated and purified by silica gel, MCI and Sephadex LH-20 column chromatography, and their structures were determined based on physicochemical constants and spectroscopic analysis including NMR and MS.
RESULTTwelve compounds were isolated and identified from Datura stramonium, they were N-trans-feruloyl tryptamine (1), hyoscyamilactol (2), scopoletin (3), umckalin (4), daturaolone (5), daturadiol (6), N-trans-ferulicacyl- tyramine (7), cleomiscosin A (8), fraxetin (9), scopolamine (10), 1-Acetyl-7-hydrox-beta-carbol-ine (11), 7-hydroxy-beta-carbolinel-propionic acid (12).
CONCLUSIONCompound 2, 7, 9 and 12 were obtained from Datura genus for the first time, whereas compound 1, 4, 8 and 11 were obtained from the Solanaceae family for the first time.