Study on pharmacokinetics of danshensu sodium in danshen dripping solution in Beagles.
- Author:
Ling ZHOU
1
;
Jun ZHANG
;
Liyan XIE
;
Jie XU
;
Jing JI
;
Jianming CHENG
;
Wenzheng JU
;
Zixiu LIU
;
Shijia LIU
;
Hengshan TAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chromatography, High Pressure Liquid; Dogs; Drug Stability; Drugs, Chinese Herbal; pharmacokinetics; Female; Lactates; pharmacokinetics; Male; Solutions
- From: China Journal of Chinese Materia Medica 2012;37(3):373-376
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect pharmacokinetics of Danshensu Sodium in Danshen dripping solution in Beagles.
METHODDanshen dripping solution was dripped intravenously into healthy Beagles at a dose of 10 mL x kg(-1). Their plasma samples were extracted with acetic ether, the blood concentrations were determined by HPLC method.
RESULTDanshensu Sodium showed a good linear relationship within the range of 0.225-18.000 mg x L(-1), with the lowest detectable limit of 0.113 mg x L(-1). Its pharmacokinetic parameters were as follows: tmax was 30 min, Cmax was (9.5742 +/- 2.3715) mg x L(-1), t1/2 was (19.23 +/- 2.97) min, CL was (0.0127 +/- 0.0030) L x min(-1) x kg(-1), AUC(0-tn) was (474.954 +/- 95.483) mg x min x L(-1) and AUC(0-infinity) was (482.494 +/- 95.353) mg x min x L(-1).
CONCLUSIONThe accurate, stable and reliable blood concentration method shows a one-compartment mode of Danshensu Sodium in Beagles.
