Clinical efficacy of bushen huoxue qubi decoction on treatment of knee-osteoarthritis and its effect on hemarheology, anti-inflammation and antioxidation.
- Author:
Ge GAO
1
;
Hong WU
;
Jing TIAN
;
Jinfeng DU
;
Xi XIE
;
Jiesheng GAO
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Antioxidants; adverse effects; pharmacology; therapeutic use; Case-Control Studies; Drugs, Chinese Herbal; administration & dosage; adverse effects; therapeutic use; Female; Hemodynamics; drug effects; Humans; Interleukin-1beta; blood; Male; Middle Aged; Nitric Oxide; blood; Nitric Oxide Synthase Type II; blood; Osteoarthritis, Knee; drug therapy; metabolism; Treatment Outcome; Tumor Necrosis Factor-alpha; blood
- From: China Journal of Chinese Materia Medica 2012;37(3):390-396
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prove the clinical effect and mechanism of Bushen Huoxue Qubi Decoction on treatment of knee-osteoarthritis.
METHODNinty-six knee-osteoarthritic patients accompanied with symptoms of liver and kidney deficiency and blocked main and collateral channels were divided into two groups randomly. Patients in the treatment group (n = 48) were administrated by Bushen Huoxue Qubi Decoction one bag/day for four weeks; and those in the control group (n = 48) were given diacerein (50 mg Bid, Po) and celecoxib (0.2 Qd, Po) for four weeks. The changes of VAS score, Womac score, relative viscosity, aggregation index and IL-1beta, NO, iNOS, LPO, SOD in serum were observed. Adverse effects were determined during follow-up visit and detection for blood routine and hepatic and renal functions.
RESULTIts clinical control rates as per Western medicine and TCM standards for treatment of knee-osteoarthritis and effective rate were 33.3%, 37.5% and 97.9% respectively, which was remarkably higher than those in the control group (18.8%, 20.8% and 95.5%). Their difference showed statistical significance, P<0.05 or 0.01. Bushen Huoxue Qubi Decoction had an effect in obviously improving hemarheological index in 42 days and inhibiting IL-1beta, NO, iNOS and LPO better than the control group, by the contrast of 58.6% vs 47.3%, 50.1% vs 36%, 55.1% vs 41.9% and 46.7% vs 20.6% (P<0.05 or P<0.01). The treatment group also displayed a higher SOD capability the control group (2 514.71 +/- 812.65) vs (2 013.41 +/- 781.3), (P<0.01). Both groups reported no adverse effect.
CONCLUSIONBushen Huoxue Qubi Decoction has a better efficacy on knee-OA than traditional treatment methods (diacereinand + celecoxib) and showed no adverse effect.
