Study on chemical constituents of Lycopodium alkaloids.
- Author:
Huijie LIU
1
;
Ye WANG
Author Information
- Publication Type:Journal Article
- MeSH: Alkaloids; chemistry; Chromatography, High Pressure Liquid; Lycopodium; chemistry
- From: China Journal of Chinese Materia Medica 2012;37(4):475-477
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the alkaloid chemical constituents of Lycopodium japonicum.
METHODCompounds were isolated and purified by such methods as silica gel column chromatography, RP-C18 reversed phase column chromatography, Sephadex LH-20 column chromatography and Waters semi-preparative liquid chromatogram, and their structures were identified based on physicochemical property and spectrum data.
RESULTNine known alkaloid chemical constituents were isolated and identified, they were lycodoline (1), lucidioline (2), alpha-obscurine (3), lycopodine (4), lycoposerramine-L (5), lycoposerramine-M (6), 11alpha-O-acetyl-lycopodine (7), des-N-methyl-a-obscurine (8), clavolonine (9).
CONCLUSIONCompounds 4-9 were obtained from L. japonicum for the first time.
