Experimental study on inhibitory effect of GFW on transplantable tumor cell metastasis in S180 tumor-bearing mices.
- Author:
Xiaoqing LUO
1
;
Jiyu SUN
;
Qi WANG
;
Jie GUAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antineoplastic Agents; pharmacology; Drugs, Chinese Herbal; pharmacology; Gene Expression Regulation, Neoplastic; drug effects; Hyaluronan Receptors; metabolism; Male; Mice; Neoplasm Metastasis; Sarcoma 180; blood; metabolism; pathology; Vascular Endothelial Growth Factor A; blood; Xenograft Model Antitumor Assays
- From: China Journal of Chinese Materia Medica 2012;37(4):520-523
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the effect of GFW on tumor cell metastasis in S180 tumor-bearing mice.
METHODS180 tumor-bearing mice model were replicated and divided randomly into 4 groups: the model group, the GFW group, the cyclophosphamide group and the combination administration group. VEGF in serum on each group was detected by ELISA, and the expression of metastasis suppressor gene nm23H1 and cell adhesion molecule CD44 in Sarcoma were detected by SABC immunohistochemical assay.
RESULTCompared with the model group, the GFW group showed a significant decrease in VEGF in serum (P < 0.01). From their statistically significant difference, GFW was proved to promote the expression of metastasis suppressor gene nm23H1 and inhibit the expression of cell adhesion molecule CD44 (P < 0.05).
CONCLUSIONGFW has an effect on inhibiting tumor metastasis to some extent.
