Effect of Euphorbia kansui on urination and kidney AQP2, IL-1beta and TNF-alpha mRNA expression of mice injected with normal saline.
- Author:
Huiyu LI
1
;
Fan LEI
;
Yugang WANG
;
Xinyue XIAO
;
Jun HU
;
Xianlong CHENG
;
Dongming XING
;
Lei HUA
;
Ruichao LIN
;
Lijun DU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Aquaporin 2; genetics; Euphorbia; Interleukin-1beta; genetics; Kidney; drug effects; metabolism; Male; Mice; Mice, Inbred ICR; Plant Extracts; pharmacology; RNA, Messenger; analysis; Tumor Necrosis Factor-alpha; genetics; Urination; drug effects
- From: China Journal of Chinese Materia Medica 2012;37(5):606-610
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of Euphorbia kansui (E. KS) alcohol extracts on urination and kidney-related expressions of mice injected with normal saline and to discuss its impact on kidney.
METHODMice intraperitoneally injected with normal saline were observed for urination and changes in kidney-related histiocytic factors of after intragastrical administration of E. KS and compared with normal mice.
RESULTE. KS alcohol extracts can promote urination of mice injected with normal saline and enhance peripheral serum creatinine, with no obvious pathological change showed in tissue sections. It had a certain effect on reducing AQP2 expression and enhancing TNF-alpha expression.
CONCLUSIONEuphorbia kansui in large dose has a remarkable effect on kidney but may be accompanied with pathological reactions to some extent, especially the dose of 1.2 g x kg(-1). The pathological reactions may be related with increased serum creatinine and TNF-alpha expression.
